Regular use of painkillers can dramatically improve the treatment of cancer, suggests the study.
Aspirin and ibuprofen increased by 25 per cent to 78 per cent for head and neck tumors.
A third of the cancer that killed 4,000 Britons a year changes the gene PIK3CA.
The University of California San Francisco has found a "strong clinical advantage" of painkillers to cope with the mutation.
Writing in the Journal of Experimental Medicine, the authors say this is the first study to show "a strong clinical advantage" for the regular use of NSAID in patients with head and neck cancer with mutations in the PIK3CA gene.
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Dr Jennifer Granddes, a professor of head and neck surgery, and a senior author of the paper, said: "Our results suggest that the use of NSAIDs could significantly improve the results not only in patients with throat and neck cancer, but also in patients with other types of cancer that contains a PIK3CA mutation.
"The size of the obvious advantage is strong and potentially can have a positive impact on human health."