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An unused source of potential new antibiotics – an overview of Eurasia



Because current antibiotics are reduced with effectiveness against
pathogenic-resistant molds, researchers look for potential
replacing some incredible places. Now the team identifies bacteria
with promising antibiotic activity against known pathogens – even
dangerous organisms, such as a microbe that causes MRSA infections –
in the protective mucus that coats young fish.

Researchers will present their results today to the American
Chemical Society (ACS) National Meeting and Exhibition spring 2019.
ACS, the world's largest scientific society, holds the meeting here
through Thursday. It contains nearly 13,000 wide presentations
a range of scientific topics.

"For us, every germ in the marine environment that can provide
the new compound is worth exploring, "says Dr. Sandra Lozgen
chief researcher of the group.

According to Losgen, who is at Oregon State University, is a novel
Chemical reagents have been found in human microbiom, the marine
the equivalent remains relatively neutral. One potential mine
microbes are mucus that covers the surfaces of the fish. This sweet
the substance protects the fish from bacteria, fungi and viruses in their
environment, trapping microbes before they cause infections. On
slimes are also rich in polysaccharides and peptides that are known to have
antibacterial activity.

"Fish mucus is really interesting, because the surroundings of fish
live in is complex, "says Molly Austin, undergraduate chemistry
a student in the laboratory Lozen, who conducted some studies.
"They are in contact with their environment all the time with many
pathogenic viruses. "According to Austin, it would be interesting
to find out if anything in the mucus that protects the fish can
actually help to protect people.

Associate Erin (Misti) Paige-Tran, PhD, who is in California
State University, Fulverton, supplies the mucus, shaven from the juvenile
deep sea and surface habitat fish caught outside Southern California
coast. The team examines young fish because they have less developed ones
the immune system and more mucus on the exterior of their scales that could
contains a higher concentration of active bacteria than adult fish.

Loesgen, Austin and graduate Page Mandelin isolated and
screened 47 different types of bacteria from the slime. Five bacteria
extracts strongly inhibit methicillin-resistant S. aureus (MRSA), and three inhibited Candida albicans,
fungus pathogens for humans. Bacteria from mucus received from a
especially Pacific pink perch showed strong activity against MRSA and
against the cell line of colon cancer. Austin now focuses his work
on Pseudomonas aeruginosa, Gram-negative bacteria obtained from
that the fish, to learn of many potentially interesting phenasine naturally
products and antibiotics that make this bacterium.

While team members are interested in new sources of antibiotics
to help people, they also look for other ways to apply this
knowledge. For example, a study of the mucous mucus may also help reduce it
the use of antibiotics in the cultivation of fish, leading to better antibiotics
especially aimed at the microbes that attach to certain fish species.

But, first, researchers want to understand more fundamental
questions. For example, "We do not even know what a healthy microbial is
is, "says Lozenge. She explains that bacteria are unclear
they studied in fish leagues were typical of their microbials and everything
protecting their hosts, or if these bacteria just happened to do
driving these individual fish. Learn more about healthy fish
microbiomas and how they affect environmental factors in the Pacific
can help inform about conservation, researchers say.


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