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Research reveals genes predicting dengue severity – Current life – updated news from Uruguay and the world



Thus, study authors at Stanford University, California, USA believe that the way to prevent this infection is affecting 200 to 400 million people every year in the world and It causes death of about half a million of them.

The researchers focused on the common genetic features of patients who presented cases of dengue from advanced to severe.

The report, published in the scientific journal Cell Reports, analyzed data from the five previous trials, where 20 genes emerged in all patients who developed severe cases of the disease.

"We did not compare healthy patients with infected patients, we compared those who had uncomplicated dengue infection with those who developed a serious dengue," said Pursh Hatri, a professor of medicine and biomedical data in medicine at the Stanford School of Medicine. from the authors of the study.

In this way, the researchers succeeded in forming a group of genes that allow them to know whether the patient is more prone to get worse with this disease, which is spread from mosquito bites, generally known as "Aedes aegypti".

To confirm the validity of the identified genes, the researchers conducted a joint analysis with the Foundation for Clinical Research at Vale del Lilli, in Cali (Colombia).

In the initial stages, 34 participants with dengue were evaluated, predicting the development of infection based on 20 previously identified genes.

The results coincided with an effective diagnosis of who would develop the infection to a greater extent and who would not.

"Of course, this sample of the population is small and we want to confirm our data in the larger populations," said Katri, noting that a new study will be developed in Paraguay.

With a larger sample of the population, there is also the potential to refine the data that could potentially lead to a reduction in the number of genes, "added Shirith Ainev, a professor of medicine and microbiology and immunology at Stanford and co-author of the study.


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