White House press secretary Sarah Sanders told a religious television network that God "wants Donald Trump to become president".
Ms. Sanders argued in an interview with the Christian Broadcasting Network (CBN), saying that this was the reason Mr. Trump was in power.
The press secretary also said it was "very difficult" to take lessons from the morale of the Democratic Party.
The Democrats attacked Trump's proposed borderline as immoral.
American evangelists strongly support the president.
Washington Post reports Mr Trump won 80% of the evangelical elections in 2016, most of Republican presidential candidates Mitt Romney and John McCain in the previous election.
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CBN aired an interview with Ms. Sanders on Wednesday, conducted by David Brody and Jennifer Vishon.
Answering Mr. Brady's question about Mr Trump's position, Ms. Sanders said: "I think God is inviting all of us to fill different roles at different times and I think he wants Donald Trump to become president."
"That's why he is there and I think he has done a tremendous job in supporting many things that people of faith really care about."
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When asked about the position of parliament speaker Nancy Pelosi on the proposed borderline – a split issue at the heart of the longest closing down of the US government in history – the press secretary attacked Ms. Pelosi's proposal that such a barrier is immoral.
"Frankly, at this point it is very difficult to hold a lecture from the Democrats about what is morally and which is not," she said, calling it "ridiculous accusation" and saying that Pelosi "can complain even to comment ".
"Protecting people from your country … is the primary duty to be the president of the United States," said Ms. Sanders.
The interview comes days after Mr. Trump announced his support for studying the Bible.
Several states have legislation in anticipation that they will make Bible literacy courses part of state education.
The American Civil Liberties Union attacked Mr. Trump's support.
"More often than not, the public Bible classes for the Bible resemble Sunday school lessons and violate the rights of the First Amendment to students and parents," said senior lawyer Heather Weaver.
"Public schools are about education, not religious indoctrination".