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In major meta-analysis, omega-3 fish oil supplements linked to lower cardiovasc

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People who received omega-3 fish oil supplements in randomized clinical trials had lower risk of heart attack and other cardiovascular disease (CVD) events compared to those given placebo, according to a new meta-analysis from Harvard T.H. Chan School of Public Health and Brigham and Women's Hospital. Researchers found an association between daily omega-3 supplementation and reduced risk of most CVD outcomes, including heart attack, coronary heart disease death, and CVD death, but did not see a benefit for stroke. In addition, higher doses of omega-3 fish oil supplements appeared to provide even greater risk reduction.

The study will be published online September 30, 2019 in the Journal of the American Heart Association.

"This meta-analysis provides the most up-to-date evidence regarding the effects of omega-3 supplementation on the risk of multiple CVD outcomes. We found significant protective effects of daily omega-3 supplementation against most CVD outcome risks and associations. be in a dose-response manner, "said first author Yang Hu, a postdoctoral fellow at the Harvard Chan School of Nutrition.

While observational studies have shown an association between fish consumption and lower heart disease risk, results from randomized controlled trials (RCTs) have been inconsistent. Two reviews published last year did not find clear evidence for benefit.

In this new analysis, the researchers did an updated meta-analysis that included three recently completed large-scale trials, which increased the sample size by 64%. The total population analyzed by Hu and colleagues included more than 120,000 adults in 13 randomized trials worldwide. The analysis included the VITAL trial, the largest randomized trial of omega-3s to date.

The findings showed that people who took omega-3 fish oil supplements daily, compared with those who took a placebo, lowered their risk for most CVD outcomes except stroke, including an 8% reduced risk for heart attack and coronary heart disease (CHD) death. . The association was particularly evident at higher doses of omega-3 fish oil supplementation. This finding may suggest that marine omega-3 supplementation dosage above 840 mg / day used in most randomized clinical trials may provide greater reductions in CVD risk. Given that several million people experience these CVD events worldwide each year, even small reductions in risk can translate into hundreds of thousands of heart attacks and CVD deaths, according to researchers.

"Although public health recommendations should focus on increasing fish consumption, having an overall heart-healthy diet, being physically active, and having other healthy lifestyle practices, this study suggests that omega-3 supplementation may play a role in appropriate patients," said a senior. author JoAnn Manson, chief of the Division of Preventive Medicine at Brigham and Women's Hospital and professor in the Department of Epidemiology at Harvard Chan School. Manson is also the Director of the large-scale VITAL trial of omega-3s.

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More information:
Journal of the American Heart Association (2019). DOI: 10.1161 / JAHA.119.013543

Provided by
Harvard T.H. Chan School of Public Health

                                                 In major meta-analysis, omega-3 fish oil supplements linked to lower cardiovasc (2019, September 30)
                                                 retrieved 30 September 2019

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