The Belgian wing has become doubtful in the game, but it is expected to play some role at Stamford Bridge.
Ross Barkley will be in the midfield at Jorginho and Noloch Golo Kante.
Crystal Palace is available to Wilfried Zaha, but Connor Wickham joins Christian Benteke, Scott Dann and Joel Ward at the management table.
Eden Hazard, coach of Maurice Sarri, said: "Yesterday, Eden was a great part of the team, perhaps not ready for a 90-minute game because it was the first training in the past two weeks.
"But you'll probably be able to play for 40, 45 minutes, so it's important for us."
Crystal Palace manger Roy Hodgson: "We can not disguise the greatness of the task.
"We can not guess it will be easier than it is, but we played well against Liverpool and Arsenal.
"I'm not preparing for the teams to underestimate us, because I think we've burned it so we can not estimate it, and I do not think anyone finds it an outdated conclusion."
Chelsea is hoping to score 27 points in the Premier League over Liverpool.
However, Manchester City is the first player to win and win 29 against Southampton.
Chelsea boss Sarri admitted he did not know whether Victor Moses or Danny Drinkwater would be in the club in the future.
He said: "I think the situation is that Drinkwater does not fit in midfield (before or before Fabregas) in two midfields, two months ago I told him what I thought.
"Moses is much more suitable for players than a wing like a winger or a full back, they have a future at Chelsea, I do not know they have to improve, but their features are a bit different.
Chelsea predicted Crystal Palace
(4-3-3) Arrizabalaga; Azpilicueta, Luiz, Rudiger, Alonso; Jorginho, Kante, Barkley; Willian, Hazard, Morata