Tuesday , July 27 2021

The coffee protects against fatty liver caused by a high-fat diet



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Areas – Riyadh

Coffee consumption is inversely related to the risk of non-alcoholic fatty liver disease (NAFLD). There is still a gap in the literature on gastrointestinal mechanisms involved in the effect of coffee consumption in the prevention of non-alcoholic fatty disorders of the liver. In a study published by the University of Cambridge in the Journal of Natural Science, 24 mice were divided into 3 groups, each subject on a specific diet for 12 weeks: the first standard diet and the second high-fat diet and the third high-fat diet with coffee No caffeine . The study concluded that coffee consumption reduces hepatic lipid degeneration caused by high-fat diet and also reduces cholesterol and glucose levels.
Compared with mice that were only subjected to fat diets, mice with the same regimen, but with coffee had higher amounts of non-fats in the colon and more free fatty acids in the 12th and colon. Mice who had coffee had a similar amount of energy compared to those who had a fat-free diet without coffee, but since the eighth intervention week the brown group received significantly less weight over time. The data showed that coffee prevented the occurrence of soft fatty liver diseases caused by high-fat diet in mice, by reducing the deposition of hepatic fat and metabolic abnormalities by modifying the pathways that support lipid oxidation in the liver, the cholesterol flow in the intestines, the metabolism of energy and intestinal permeability. Hepatocellular benefits and coffee-induced metabolism were also associated with changes in the small intestine.

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