Monday , January 25 2021

Mushroom improves water balance



Fluconazole, an approved fungal drug, has now discovered surprisingly new properties. The substance helps to extract urine water, as rodent experiments have suggested. Road to therapeutic therapeutic application z. However, in rare genetic kidney diseases it is still not so easy.

More water returns to the body

Fluconazole, an approved fungal drug, has now discovered surprisingly new properties. The substance helps to extract urine water, as rodent experiments have suggested. Road to therapeutic therapeutic application z. However, in rare genetic kidney diseases it is still not so easy.

To 20 liters of urine rush every day in the bathroom, and they also need to drink as much, This limits the life of patients with water hammers (Diabetes insipidus) strong. The kidneys do not drain enough water from the urine. this may have genetic causes, but also be caused by drugs, for example, These people may in the future have true antifungal drugs called fluconazole.

Fluconazole brings more water back into the body

The drug is activated aquaporins in the kidney cells, which are stored in small doses of vesicles. Once activated, they form Pores into the surface of the cell through which the water molecules flow can. on The kidneys transport water from the urine back to the body,

Usually this will do The process is precisely controlled by the hormone of vasopressinIf the hormone is missing or can not work on the cell, it can lead to massive loss of free water in the urine. fluconazole Interestingly, even without a hormone, it does, at least to some extent water resources to is regulated, About 30% of normal water recovery can return fluconazole, even without vasopressin in mice.

There is no therapy for all patients

Fluconazole is only useful something if the aquaporin machine is still intact in the kidney cell, Patients whose Aquaporin gene mutated is, it can be one future fluconazole therapy for example does not help,

However, there is hope for the affected, whose body produces too little vasopressin for hereditary causes, or whose renal cells are not sensitive to the hormone due to the mutation. In addition, about half of people who need to take lithium as a medicine, too much water. Also, their kidneys no longer respond enough to the hormone and in principle, it can benefit from fluconazole,

Effect in the cells of the kidney canals

Each person produces in the kidneys every day with a full 180 liters of primary urine. In the end, however, only a few liters of a day may appear as urine. To this end, the small tubes that lead the urine to the renal pelvis attract more or less water from the liquid as needed. Decisive for the hormonally controlled fine-tuning of this process are the multitude.

At this point, "rediscovered" fungal drugs intervene. Under the influence of drugs Aquaporins migrated to the surface in the cell. also, improved Fluconazole Day Water transport in collecting tubes of mice,


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