A genetic mutation that prevents a person from developing HIV increases the risk of early death. A Chinese scientist used the Crispr gene scissors to cause such a mutation in twin babies.
Chinese scientist Jiankui He claims to have created a genetic mutation of a twin girl born in 2018 using ginger scissors Crispr, which means they can not develop HIV. But this mutation is associated with an increase in mortality of 21 percent. This is reported by scientists at the University of California (UCLA) in Berkeley.
The CCR5 gene encodes a protein found, inter alia, on the surface of the immune cells. There it helps HIV viruses attack and infect them. An appropriate mutation, called delta 32, deactivates this protein.
Geni babies: HIV immunity increases the risk of death
Mutation is also natural. It is rare among Asians, but is found in about 11 per cent of northern Europeans. US researchers have now examined more than 400,000 genomes and related health data in the UK database and found that people with two mutated copies of the gene had a significantly higher mortality rate between 41 and 78 years of those with one or no copies, Immune the genes for HIV thus increase the risk of death
Previous studies linked the two mutant copies of the CCR5 gene to a fourfold increase in mortality after infection with influenza. The higher overall mortality rate may reflect this greater susceptibility to death from influenza.
The effect of gene manipulation is not predicted
The researchers, however, believe that there are no other explanations for this. Because the CCR5 encoding protein, which does not work for those who have a mutation in both copies of the gene, is involved in many body functions.
"Apart from the many ethical issues associated with Crispr babies, it's still very dangerous to introduce mutations without knowing the full effect of these mutations," said research leader Rasmus Nielsen, an associate professor of Integrated Biology, in a press release.
Protection against smallpox, dengue and tongue
"Here's a functional protein we know has an effect on the body and is well conserved in many species, so it's likely that the mutation that destroys the protein on average is not good evolutionary mechanisms have destroyed this protein for a long time," continues Nielsen.
There is evidence that the mutation is associated with increased survival and protection against measles and flaviviruses, including the dengue, zygote, and western Nile viruses, adds the study author Xinzhu Wei.
Crispr is too dangerous for manipulations with microbial lines
Despite these potential benefits, the potential side effects of genetic mutations in adult somatic cells, as well as cells from embryonic mythological lines, should be treated with caution, according to researchers.
"I think there are many things that are not currently known about the functions of the genes," Wei said. "Crispr's technology is too dangerous to use for the moment's reprocessing." The current study was published online in the journal Nature Medicine.
He was released after experiments from his university in Shenzhen, Shenzhen and received a ban on research.
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