People who were diagnosed with familial hypercholesterolemia at a young age, inherited elevated LDL cholesterol, after twenty years of statin treatment had no evidence of increased atherosclerosis compared to brothers and sisters without the disorder.
Shows new results in the New England Journal of Medicine.
Researchers in the Netherlands followed 214 patients who initially participated in a randomized trial of statin pravastatin. Twenty years later, the thickness of the most decisive layer of the vessel's thickness was measured in their one carotid artery, a common marker for the development of atherosclerosis. It turned out that there was no difference here with the brothers and sisters.
The researchers also found that children with family hypercholesterolemia fared much better than their parents with the same cholesterol disorder. Of the parents who had access to statin therapy only later in life, 7% died of cardiovascular disease at the age of 39, compared to 0% of children.
The corresponding proportion affected by cardiovascular events, such as myocardial infarction and stroke, was 26 percent and 1 percent at the same age.
Researchers note that these positive results were achieved despite the fact that only a small proportion of patients were able to lower their cholesterol levels below target levels.
Read the study abstract:
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