They hope that one day their project will lead to much cheaper life saving therapies. Protein-based drugs, such as protein-based biological drugs, such as Herceptin and Avastin biological medicines (the latter also in the use of moist form of age-related macular degeneration), can be effective when they are give up well-established pharmaceutical products, but their disadvantage is that they are very expensive, say the BBC. Research conducted at the Institute Roslincan lead to cheaper production processes, the Slovenian Press Agency reports.
The publication is in a scientific publication BMC Biotechnology.
A team of researchers from the Roslin Institute has changed the genome of chickens so that their eggs contain large amounts of high-quality proteins. Three eggs contain a dose of clinical effect, they say, and hens spend hundreds of eggs annually.
These proteins will now be used for research, but laboratory tests have already shown that they are just as effective as comparable drugs.
What are actually secrets …
For now, chickens are genetically modified to produce two types of proteins. One is actually a macrophage CFS, which can be used to stimulate the damaged tissue in order to repair it. They develop it in human and pig variants.
The other is interferon alpha-2a. It is a human own protein that reacts as part of the human immune system. It has anti-virus features, according to the doctor Lisa Herrone Roslin Technologies also discovered anti-knocking properties. "This is a protein that uses some time to treat hepatitis in certain forms of cancer" she added.
… and what else could be
A team of researchers is convinced that a set of proteins that will "turn over" transgenic chickens, Expand it. Chickens themselves do not affect the presence of human proteins in their body, they also live better than chickens in battery mode because eggs are usually used as normal.
More eggs in the presence of a cock
The research is conducted in a protective object within the Roslin Institute, where dozens of transgenic animals are grown in spatial chickens, whose task is to boil 300 eggs a year. They also have a dual role in the company.
Chickens are more likely to turn over eggs if there are shallow ones in their vicinity. In addition, several male transgenic birds are needed for breeding. They are not clones, but come into the world in a conventional, biological way.
"In the hen we have a cock that can produce many chickens in a very short time" said Professor Helen Sang from the institute.
Can not be produced in a laboratory
Eggs rolled from chickens then travel to the cacophony of chickens from the hen separated from the laboratory, where they are crushed, while egg yolks are separated from the proteins. Rummenovci do not use it, and the protein is one that contains large amounts of medically significant proteins.
"These proteins are really expensive to produce because they can not be synthesized in the laboratory" said Dr. Heron. "They need a living system because proteins are very large and very complex molecules that require the whole cell structure for proper production" Add Herron.
Therefore, transgenic chickens could become pioneers in the production of better and cheaper drugs. Even in this study, as with all those who promise, there is a problem. The real development of the turning point also needs to take several decades of further research and experiments. Path to t. i. Drugs for orphan rare diseases can be much shorter, and medicines for animals are on the market before that, STA reported.