San Diego, California (May 9, 2019) – Patients who have eliminated the appendix are likely to develop Parkinson's disease from those whose allowance remains in place, according to the largest study to resolve the relationship between the two conditions. A retrospective study involving more than 62 million entries from patients from 26 health systems will be presented on the Diagnostic Diseases ® (DDW) 2019 Diary.
"Recent studies of the cause of Parkinson's disease are centered around alpha-synuclein, a protein found in the gastrointestinal tract early in the onset of Parkinson's disease," says Mohamed Z. Sheriff, Doctor of Science, Doctor of Science and Doctor at the University of Kays West Bernd and University Hospital Cleveland Medical Center, Ohio. "This is why scientists around the world are examining the gastrointestinal tract, including the appendix, for evidence of the development of Parkinson's disease."
Previous findings of appendectomies and Parkinson's disease were inconsistent, with some studies that showed no connection and a recent study from Europe that showed patients who still had their appendix were more likely to develop Parkinson's disease. This controversy prompted Dr. Sheriff and colleagues to seek answers to the question using data from the United States based electronic health records based in Ohio, which collects data from 26 major integrated health systems.
The researchers analyzed electronic health records representing more than 62.2 million patients and identified those who had an appendectomy and were diagnosed with Parkinson's disease at least six months later.
They found that 488,190 patients who underwent appendectomy, 4,470, or .92 per cent, developed Parkinson's disease. Of the remaining 61.7 million patients with no appendectomies, they identified only 177.230, or .29 per cent, who developed the disease. According to this analysis, patients who had an appendectomy had more than three times more chance of developing Parkinson than those who were not.
The researchers found similar levels of risk in all age groups, regardless of gender or race. Apart from the six-month release period programmed into their initial database request, the researchers could not show the ten identified records exactly how much time had elapsed after an appendectomy until Parkinson's disease was diagnosed.
"This research shows a clear link between appendice or the removal of appendice and Parkinson's disease, but it's just association," said Dr. Sheriff. "Further research is needed to confirm this link and better understand the mechanisms involved."
DDW Presentation details
Mohamed Z. Sheriff, MD, will present the data from the study, "Parkinson's disease is more prevalent in patients with appendectomies: a national population-based study", abstract 739, on Monday, May 20th, at 4:18 am. PDT. For more information about the studies conducted, as well as the availability schedule for the selected researchers, visit http: // www.
Week of Digestive Diseases ® (DDW) is the largest international gathering of doctors, researchers and academics in the field of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly sponsored by the American Association for the Study of Liver Disease (AASLD), the Institute of American Gastroenterological Associations (AGA), the American Association of Gastrointestinal Endoscopy (ACCE) and the Association for Surgery of the Alimentary Tract (SSAT), DDW 18 – May 21, 2019 year, in San Diego, California. At the meeting, more than 5,000 abstracts and hundreds of lectures on the latest achievements in GI research, medicine and technology were presented. More information can be found at http: // www.
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