Wednesday , April 14 2021

gene modification may be more effective than the vaccine



Researchers would find an alternative to an influenza vaccine. Their research, potentially revolutionary and published in the journal science, shows that the gene inserted into the genetic capillary of the nasal cells allows them to secrete an antibody capable of combating 59 strains of influenza virus out of the 60 subjects.

The vaccine is never 100% effective

Because the influenza virus mutates constantly and randomly, the vaccine is never 100% effective: year after year the viruses are changing enough to avoid the immune response that has developed against the virus. in the previous year: they can infect people who already have flu, and vaccination must be repeated every year.

Especially, even if it is adjusted each year according to various parameters (virus circulating the previous year and in different regions of the world, probabilistic analysis …) and if it is directed against several strains, the flu vaccine can only partially cover the viruses that actually appear. First of all, if, just like during the 2017-2017 outbreak, 2 viruses circulated: the vaccine was effective against the first (virus A (H1N1) pdm09), but not against 2. (Yamagata B, virus B), which time to develop due to for the length of the epidemic.

Ultimately, and for all these reasons, the flu vaccine can not be 100% effective, and partly because it is rejected by many French people.

Other tested strategies

There is, of course, a Graal of a universal vaccine directed against a more stable and more universal component of the virus, but we are still far from it. On the other hand, looking for other ways to fight the flu, scientists have found that some people naturally produce antibodies that can fight many strains of influenza virus.

They then created a gene capable of generating the production of these antibodies, and then were injected into the mouse's nose with a harmless viral vector ("transfection"). Murine nasal cells that received the transplant of this gene were then capable of producing this famous antibody. Sixty strains of influenza virus were then tested by inoculation into these animals and only one strain from 60 was not controlled by antibodies … but 59 was.

Multi-mode antibody

"The MD3606 multidose antibody protects mice against Influenza A and B infections after intravenous administration," the researchers conclude. 'Our results show that multi-domain antibodies have increased cross-reactivity and viral activity and can be an effective strategy to prevent influenza and other highly variable pathogens,' they added.

It's interesting, but it's in mice and it should not stop you from being immunized this year against the flu. Not even 100% effective, the flu vaccine protects against the most serious infections: last year the vast majority

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