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Nobel Prize in Physiology or Medicine, 3 US and English Scientists "Contribution to Oxygen and Cell Impact Research"



Enter 2019.10.07 19:59
| Revision 2019.10.07 21:17

"Merit for Adaptation to Oxygen in Cells"

Greg Semneca (left), Nobel Prize in Physiology (left), Peter Ratcliffe, William Kaelin / Nobel Committee pages.

This year's Nobel Prize in Physiology won three co-winners: William Kaelin of the United States, Greg Semenza and Peter Ratcliff of Great Britain.

The Nobel committee of the Carolingian Institute of Sweden (September 7) announced that three people, William G. Kathleen Junior, Greg L. Seeds and Peter J. Ratcliff, UK He was named co-winner of the Nobel Prize in Physiology. They were recognized for their work on cellular responses to oxygen concentrations.

The winners have laid the groundwork for how oxygen levels affect cell metabolism and physiological function, paving the way for new strategies to combat anemia, cancer and many other diseases, the Nobel Committee said.

They have found that HIF plays an important role in adapting the cell to hypoxic concentrations.

The Nobel Committee said: "Thanks to the in-depth research of the Nobel Prize winners, I have learned how oxygen levels regulate basic human physiological processes.

William Kathleen first identified the response to "hypoxia" in the cells.

Greg Seemens discovered HIF-1, which allows cancer cells to adapt to non-oxygenated environments. It plays a decisive role in the treatment of cancer and develops as a therapeutic agent.

Peter Ratcliff continued to work on erythropoietin, the erythropoietin hormone. We have identified a process for activation of hypoxia-induced induction factor (CIF), which is involved in the production of erythropoietin and to increase production of red blood cells.

So far, these studies have not developed a cure for cancer. However, many of these studies are ongoing.

The tumors (lumps) grow in size and fall into hypoxia. They figured out how cancer cells respond to a hypoxic state. In other words, when tumor cells become oxygen-free, they become resistant to treatment.

Previously, there have been controversies about why patients do not treat anticancer drugs well, but these joint studies have suggested a large body of research that suggests that anticancer drugs do not work well in hypoxia.

Lee Dae-ho, a professor of oncology at Seoul Asan Hospital, said: "The results of the winners' research indicate that the cancer is already in hypoxia when treated with chemotherapy or radiation. Why is the drug not working well?" about how to improve and how to improve treatment. "

Kaelin is a professor at Harvard Medical School, and Semenza is at Johann Hopkins Medical School. Ratcliffe is the director of the Target Discovery Institute at Oxford University.

The winners will receive a total of 9 million wins (approximately 1 billion won). The awards ceremony will take place on December 10.


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