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Development of a bio-simulation system for maintaining homeostasis as cells in the body



IBS Director Kim Ki Moon

Description of the photoIBS Director Kim Ki Moon

The Institute of Basic Science (IBS) announced on the 13th that Kim Ki-moon, director of a complex self-assembly research team, has developed a bio-simulation system that can maintain homeostasis as cells in our body.

The cells maintain homeostasis by accepting and consuming energy and releasing byproducts created in the process.

In the field of supramolecular chemistry, studies have been conducted to implement a system for maintaining homeostasis of cells, but there are limitations such as byproducts not accumulating and accumulating inside.

The team developed a system for cellular disposal of by-products using a self-developed hollow molecule in the form of a "cucurbituril" pumpkin.

Cucurbituril has the property of introducing tryptophan derivatives into spaces and binding them, especially in acidic conditions.

Crystal structure of Byturil stove and tryptophan derivatives

Description of the photoCrystal structure of Byturil stove and tryptophan derivatives

The team delivers acidic trichloroacetic acid as an energy source of the cucurbituril-tryptophan derivative.

Subsequently, when the heat was applied at 75 degrees, carbon dioxide, gas was blown into the air, and the remaining chloroform also evaporated naturally at a boiling point below 75 degrees.

If cucurbituryl-tryptophan derivatives are cells and trichloroacetic acid is an energy source, the cell consumes the energy source and implements a system that removes by-products by itself.

It has also been confirmed that if the acidic material is supplied continuously, it remains in crystalline form, but if the supply is interrupted, the crystal structure cannot be sustained and decayed.

When the cell loses energy, the team explains, the cell membrane bursts and the components burst.

Kim Ki Moon said: "It is expected to contribute to the development of functional materials, artificial cells, etc., which function only during fuel supply."

The findings were published online in the journal Chemistry's Angwandte Chemie last month.

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