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Smoking and diabetes have discovered the key to the dangerous combination

Diabetes, one of the most feared "enemies" to the health of our time, also because of the deteriorating profile cardiovascular riskand especially if it is linked to other heart and artery hazards (we celebrate World Diabetes Day on November 14).

In addition to obesity, overweight and metabolic disorders, which can easily be explained by the "shock" that pathological increase in blood sugar creates on the organism, the existence of harmful alliance between diabetes and smoking cigarettes. And epidemiological data confirms this: in those who smoke, diabetes it's much more common. For that to happen, however, it was not clear until now and above all it was difficult to understand how to act help the diabetic to quit smoking. Today, however, science has pierced the veil reasons of this phenomenon, even if we are only in the first experimental stages of the animals they are investigating.

Nicotine "manipulates" the pancreas

To unravel the mystery is original research conducted by Icahn School of Medicine on Mount Sinai, in New York, as evidenced by a large scholarly article published in nature. In short, the "dangerous link" between smoking and diabetes would be linkedNicotine effect. As we know, this substance manages to act directly on nervous system, and the fact that smoking cessation also goes through medication and nicotine replacement. But what the US team, led by Paul McCain, has discovered goes further.

In practice nicotine would trigger a series of "indications" when leaving the brain that are somehow restricted to a completely autonomous way production of insulin from the pancreas. And because this hormone has the primary task of controlling it elevated glucose in the blood, here's the problem: over time, reduced insulin production would lead to increase in glycemic values and therefore to the easier occurrence of diabetes.

The "connection" between nicotine and pancreas it would be related to the presence of a particular protein that responds to stimuli of a specific protein gene name Tcf7I2: Protein, in addition to acting as a control mechanism for insulin, would also act on the brain through a kind of regulation of stimuli for neurons associated with the action of nitocin.

A two-way mechanism that unfortunately turns out to be dramatically effective in a negative sense: the invisible "system" would also explain why it becomes more difficult to increase blood glucose values quit smoking, because the "control" neurons are silenced, helping the person to cope without smoking.

Blood glucose under control without smoking. And not only that

Blood sugar is a valid check parameter blood glucose rate, but values ​​can change very easily over time. It is therefore important to consider another index in diabetes control. Is called glycated hemoglobin and that is the percentage of hemoglobin that binds to glucose.

hemoglobin, which is found in red blood cells and has the task of transporting oxygen molecules, can actually become more "glycine" if it stays in contact for a long time. high glucose concentrations, as it happens exactly in the blood of a person with diabetes is not well compensated. One person with diabetes has glycated hemoglobin above the norm and tends to have higher levels of this parameter if the pathology is not adequately controlled.

Glycated hemoglobin is a lot more reliable and accurate of simple glycemia because it allows you to have a complete picture – and not just occasionally, of glucose behaviors 3-4 months before the test. Therefore, it expresses its value the average blood sugar level and provides medium-term glycemic control. In other words, thanks to regular control of glycated hemoglobin, one can obtain 'Good control of diabetes', this is the most important goal arising from the alliance between patient, GP and diabetic.

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