Friday , June 18 2021

Glyphosate, "effects on the development and reproduction of rats even in doses that are considered safe in the United States"

"Exposure to herbicides based on glyphosate (GBH), including the Review, commonly used in the world, has caused several effects on the development and reproductive system in male and female rats, even with doses currently considered safe in use"This is the final result of the pilot phase of the global herbicide study Institute Ramazzini and a network of scientific partners including theUniversity of Bologna, the hospital Genoa San Martino, National Institute of Health, of Icahn Medical School at Mount Sinai on New York and George Washington University. The fourth part of a series of articles published by the magazine discusses the research Environmental Health at the pilot phase of the study. The first results opportunity "Let's change some biological parameters of relief "as those reproductive and on microbiome intestinal, in fact, was already presented on May 16, 2018 European Parliament together with Group of Greens and then in three other articles in the same magazine. If previous scientific publications have shown that exposure to GBHs is associated with several effects negative, including the change to microbiome of rats during the developmental period, especially before puberty, in recent months, the research has concentrated precisely on sexual development.

Pilot study – 300 thousand euros for the pilot study were collected thanks to the members of the Institute Ramazzini. The research, which forms the basis for a successive long-term integrated study, aims to achieve information General for the toxicity of herbicide-based glyphosate during different periods of development (neonatal, childhood, adolescence) and to identify markers for early exposure. Glyphosate and its formulation (Roundup Bioflow, MON 52276) have been tested in rats Sprague Dawley, starting from the embryonic life up to 13 weeks after weaning, exposed to a dose of glyphosate in drinking water equivalent to acceptable daily intake according toAgency for Environmental Protection.

Effects of glyphosate on rats – Glyphosate and its formulation Review have shown adverse effects on development and reproductive system even in safe doses, such as the dose permitted daily (Dga) currently allowed in USA (also for children), equal to 1.75 micrograms per kilogram of body weight. "But we must take them into account – explains Daniele Manrioli, a researcher at the Ramazzini Institute – who in Europe on DGA Instead, it is fixed to 0.5 mg / kg. Hence the need to continue the studies to see if effects have been observed so far found even with smaller doses, as permitted Europe"Exposure to glyphosate is connected, especially with some androgenic effects, including a statistically significant increase in distance between anus and genitalia (AGD) and in men and in females, in addition to delaying the first estrus and increasing testosterone in females. "The distance between the anus and the genitals," he adds Mandrioli – e parameter significant to evaluate substances that act as endocrine disorders already at the prenatal level and are able to change the normal development of the fetus. "The increase in testosterone in women with a "masculinized" effect shows that normal hormonal balance is changed towards "increasing those characters that are typical of men"These are effects measured on both sexes, but which are more obvious females. "Long term study on GBHs starting from prenatal life, now it is necessary confirm and explore the first evidence of endocrine change and development appeared in the pilot study, "he said Fiorella Belpoggi, director of the research area at Cesare Malloni's Cancer Research Center at the Ramazzini Institute.

Glyphosate, the uncertainty of the most commonly used herbicide – Glyphosate isherbicide commonly used in history: the world uses 8.6 billion kilograms of herbicides based on glyphosate since 1974. The use of glyphosate also increased 15 times since the introduction of genetically modified crops, in 1996 In 2015 theThe International Agency for Research on Cancer (IARC) he classifies it as a "probable human carcinogen". And yet forEuropean Food Safety Authority (EFSA) it is unlikely that glyphosis is a "human carcinogenic hazard" untilEuropean Chemical Agency (EHA) stated that "available scientific evidence does not meet the criteria required to classify glyphosate as a carcinogen, mutagenic or toxic for reproduction". Evaluation of glyphosate is under way by the Environmental Protection Agency (EPA). "Scientific uncertainty about glyphosity and me GBHs – explains the Institute Ramazzini – also found political uncertainty, as demonstrated by the 5-year limited renewal of the glyphosate license, which was granted in November 2017 by the Member StatesEuropean Union".

Campaign for the audience – OnRamasini Institute, with the support of other institutes and independent universities from Europe to the United States, has now begun a campaign to finance the largest integrated long-term study of the effects of GBH "necessary to expand and confirm the first evidence that emerged in the pilot study and provide final responses to the various doubts that remain about the chronic health effects of GBH, including carcinogenic effects. " The total budget for this study is 5 million euros. according to Alberto Mantovani, director of the Department of Food and Veterinary ToxicologyHealth Institute one aspect of this Risk Assessment Study "is the greatest finding of endocrine effects and the development of a commercial formulation based on glyphosate compared to the equivalent dose of pure glyphosate. "to Mantovani "Indication that other components are present in commercial formulas can significantly increase the toxicity of glyphosate certainly deserves further investigation ".

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