Saturday , October 16 2021

Covid, one in 5 cured returns positive: Gemini study

Agreed with coronavirus and to be healed does not mean to be out of the tunnel. The virus can return. A study conducted by researchers from the University Hospital Foundation Agostino Gemeli The IRCCS and the Catholic University on campus in Rome tell us that one in five patients cured of KOVID-19, even in the absence of any symptoms, becomes positive again after a few weeks, even if less than 1% have a true reinfection.


The study, published in Yama Internal Medicine, followed 176 patients recovering from Covid-19, followed from April to June, at the Gemeli Post-Covid Center. Treatment was evaluated on the basis of standard criteria: absence of fever for 3 consecutive days, improvement of symptoms, and 2 negative molecular swabs at 24-hour intervals. During follow-up, about 50 days after diagnosis, the nasopharyngeal specimens of these patients were analyzed for the presence of total viral RNA and replicative viral RNA (RNA is the molecule in which the genetic information about the virus resides). The good news, though, is that a positive return does not mean you have a virus.
“The presence of replicative RNA in the samples,” explained Professor Maurizio Sanguinetti, a professor of microbiology at the Catholic University and director of laboratory and infectious diseases of gems, was used as an indicator of ongoing viral replication. In patients who were positive for total RNA, samples obtained at the time of diagnosis of Covid-19 were re-analyzed, requiring the presence of replicative RNA. All patients also underwent serological testing for a specific IgG / IgA virus. Of the 176 recovering patients, 32 were positive for total RNA, albeit to varying degrees. Only one of these, however, was also positive for replicative RNA of Sars CoV-2. Samples obtained from patients during the disease were tested and all were positive for replicative RNA as expected. “Let it be clear that a positive return is not a worrying fact.”

In fact, only one patient actually tested positive for both total and replicative RNA. It is an elderly subject with hypertension, diabetes and cardiovascular disease who returned positive 16 days after recovery.

And give

“In the case of this patient, the data suggest that it is a reinfection or recurrence of the infection,” said Professor Sanguinetti. upon resolution of infection “.

This study, according to experts, confirms the usefulness of performing accurate monitoring of cured patients and reinforces the concept that reinfections in cured patients are rare. What is not known at the moment is whether the new positives are contagious. In fact, the molecular test is not equivalent to a viral culture and, therefore, does not allow to determine whether a sample taken from the nasopharynx in patients contains a vital virus and is therefore transmissible.


But if research moves forward, the virus works fast. “In pandemic management, mistakes have certainly been made and we are now in an expansive phase. I refer to the free all summer. “We are still paying the bill for opening the discos,” Sanguinetti said. Especially the young. A 20-year-old may not die of covidium, but if he had a motorcycle accident, he would risk not receiving proper and timely hospital treatment. The problem is this. We all take risks, young and old. “Before a pandemic, we need to think in terms of the community and follow a few simple rules of common sense.”

Last Updated: November 13, 00:20


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