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Your Good Health: Mono symptoms can include fever, fatigue



Dear Dr. Roach: Our 18-year-old has been exposed to mono. Can you provide some information about this disease, including symptoms, treatment, complications and exposure to other family members, including toddlers and senior citizens?

F.J.M.

Infectious mononucleosis symptoms can be caused by several viruses and one parasite (toxoplasmosis), but classically, it is caused by Epstein-Barr virus, of the herpes family. Its symptoms can vary greatly, and although for most people it is a self-limiting illness, symptoms can be severe and lasting in some people, while others will have no apparent symptoms.

The cardinal symptoms (the major symptoms leading to recognition of the disease) in mononucleosis are fever; fatigue; a sore, inflamed throat; and enlarged lymph nodes. It is mostly shed by saliva, and infected people are often contagious for six months. Some people shed the virus after a natural infection for decades.

The fatigue is difficult to overstate. In some people, it can be profound, preventing exercise and studying abilities for a few weeks, up to six months. The sore throat and drainage can look like strep throat, and many people are mistakenly given amoxicillin or other antibiotics. This is a problem because rash is common and not due to allergy to the antibiotic.

The spleen can get very enlarged, as can other lymph organs, especially the lymph nodes in the throat, which can sometimes swell enough to threaten the airway. Fortunately, a rupture of the spleen and acute airway closure are rare complications.

Neurologic complications can include Guillain-Barre syndrome and damage to individual nerves. Hepatitis is more common than most people realize, but it rarely causes serious problems. A host of other complications are possible, but extremely rare.

Senior citizens are not likely to be at high risk: 90-95 per cent of adults have evidence of blood immunity. Young infants and toddlers usually have very mild disease, sometimes unnoticed clinically. Immunocompromised people, such as people with cancer or HIV, are at high risk of this disease.

Treatment is usually neither given nor effective for mononucleosis. There are a few exceptions: Airway obstruction and severe liver disease are treated with high-dose steroids. This is not used for most cases, as there are concerns about the immunity and the possibility of worsening the risk of EBV-related malignancy, especially head and neck carcinomas.

Dear Dr. Roach: Is there an over-the-counter substance or prescription that can keep me from dreaming? My dreams are exhausting. Many nights I get up from bed and go to a recliner in order to stop a dream.

Anon.

Disturbing dreams and nightmares are fairly common, but they are very rarely reported to physicians. Medications, whether over the counter or prescription, would not be my first recommendation for treatment.

While there are some medications that can cause very disturbing dreams – the beta blocker propranolol comes to mind – it is clear that bad dreams are associated with anxiety disorders or with high levels of stress or trauma. The level of disturbance you describe makes me concerned about nightmare disorder.

The first line of treatment begins with good sleep hygiene. Get moderate exercise, not before bed; avoid alcohol, caffeine and nicotine, especially before bed; sleep on a consistent schedule; avoid any screens (TV, computer, tablet, smartphone) for an hour or two before bed.

An evaluation for anxiety disorders, by your physician or a mental health professional, might be wise.

If specific therapy is considered, there are several behavioral techniques that have proven to be useful. For the person who may still require medication, prazosin is the best-studied.

Dr. Roach regrets that he is unable to answer individual letters, but will incorporate them into the column whenever possible. Readers can email questions to ToYourGoodHealth@med.cornell.edu

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