Sunday , October 17 2021

A diabetic pill created by Irish scientists can save patients from painful daily injections



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Irish researchers are working on a breakthrough in diabetic tablets that can save patients a daily round of painful injections.

The new RTE documentary called Bittersweet shows Professor David Brayden and his team at the UCD Veterinary Hospital conducting laboratory tests to make insulin available in a nutshell.

Professor Brayden said that in Ireland over the last decade there has been a huge increase in the incidence of diabetes, mainly due to a sedentary Western diet.

"The rise in diabetes is probably tenfold over the last decade," said Professor Brayden, principal investigator at Advanced Drug Delivery, UCD.

"Most of them will have type 2 diabetes and that diabetes really comes from a lifestyle, eating the wrong foods at the wrong time and not getting enough exercise."

He warned about the expected increase in chronic diseases among adolescents with increasing obesity rates.

He said: "They predict that up to one-third or a half of our children will end up obese when they reach twenty-several years." This has become quite accurate.

"The relationship between obesity and type 2 diabetes is very strong, so we know that it exerts more pressure on the system.

Professor David Brayden

"When I was a child, we spent the whole summer, but now children are on computers and phones all the time, and if they do not play sports, they do not take part in it.

"That is why we try to promote lifestyle choices in children and adults because they have to believe in providing children with the right food at a very young age."

Documentary film – part of a joint program with the CURAM CURAM Research Center in the field of medical devices and the Galway Film Center program – will be presented on Wednesday during the World Day of Diabetes.

The typical treatment for type 1 diabetes involves daily injections, while the initial type 2 treatment focuses on retarding the disease through exercise and diet, and patients later go over to needles.

Professor David Brayden and his team at UCD & # 39; s Veterinary Hospital are working on the preparation of oral insulin because they are convinced that patients are much more receptive to taking pills than injecting themselves.

"We know that because inhaled insulin has been reached, we know that patients prefer other routes than injections.

"If patients with type 2 diabetes have switched to previously injected insulin, the results are better for the patient.

"But these patients tend to delay because it is a huge psychological leap that says I will be injections for the rest of my life.

"Even if we could have a fast-acting fast-food tablet, that would be quite an achievement, and the ultimate solution would be to try and avoid injections altogether when we are able to give long-acting insulin tablets."

He said that using nanotechnology or placing the medicine on tiny particles in a capsule tablet means that they can be placed directly in the intestinal wall and bypass other organs.

Suvi and Rosie Coffey, who appear in the documentary film Science on Screen, Bittersweet – The Rise of Diabetes.

He said: "Patients usually take insulin subcutaneously, which means that organs outside the liver, its intended purpose, will get high levels of insulin that they do not need.

"This will lead to side effects, such as weight gain and other undesirable events in later life.

He added: "We do not conduct clinical trials, but the preparation can be used by clinicians and pharmaceutical companies.

"The point is that they will continue testing and test them in patients with diabetes."

Professor Derek O & # 39; Keeffe, a consultant physician, Galway University Hospital and NUI Galway, said Bittersweet shows the tacit burden of chronic illness on young patients and their families.

He said: "As a clinician, my job is to help patients on this journey and give them strength to cope with their disease states, using the latest innovations to let them live the best they can."

Suvi Coffey, the mother's Dublin mother, Rosie, tells the document that she will not allow type 1 diabetes to affect her daughter, Rosie.

"Her life will be the same as any of her children her age, and if she goes on, I think she will be stronger and a little more resilient." She is an amazing, amazing, strong girl. "

Bittersweet – The Rise of Diabetes will be broadcast on RTÉ 1 on Wednesday, November 14 at 11.10.

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