Scientists have developed novel drug which can block glioblastoma – the deadliest form of brain cancer – from spreading.
The tissue in our bodies is largely made of liquid. It moves around the cells and is essential for the normal function of the body. But in some cases, this fluid can do more harm than good.
In people who have glioblastoma, this fluid has a much greater pressure, causing it to move quickly and forcing the cancer cells to spread.
The AMD3100 drug, which was already used in clinics, has been found effective in preventing the inevitable spread of cell cancer, researchers say.
"I hope that the drug we used to block the flow of stimulation is currently being used in patients who may physicians when considering convection use, will combine it with this drug," said lead author Chase Cornenison, a postdoctoral researcher at the Polytechnic Institute in Virginia and State University.
In a study published in the journal Scientific Reports, the team investigated the flow of interstitial fluid – which surrounds the cells in the body – in the spread of glioma cells.
Comprised of circulating cerebrospinal fluid, cell waste, and blood plasma, the interstitial protein flow is previously associated with an increased invasion rate of glioblastoma or tumor cells of the brain.
The researchers tested the drug AMD3100 and found that it could block the rapid movement of interstitial brain flow and the spread of cancer cells.
They also tested a drug for mice with glioblastoma to be tested as a specific approach to delivering cancer treatment, called convection-enhanced delivery, caused glioma cells to attack the rest of the brain.
"That (glioblastoma) is so deadly, and there has been no change in the response to treatment in recent decades. Something needs to change … Looking at the flow of fluids, there may be an answer out there that we have not seen," added Jennifer Monson, assistant professor .
Published: November 21, 2018 16:11