PRAGUE The team of Pavel Jungwirt from the Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, in cooperation with colleagues from the Czech Republic and Germany, described an unknown mechanism of passive transport of peptides to cells without an intermediary. The easy transport of drugs directly to the cells is one of the aims of the pharmaceutical industry. The Institute informed about it in today's press release. The test results were published by Proceedings of the National Academy of Sciences of the United States (PNAS).
The ability of short peptides to penetrate cells was first observed in HIV research and is now used to transport drugs into cells. Until now, this is usually done via a transport bag, a so-called vesicle, which separates from the cell membrane and surrounds the transported substance. The healing molecule should be re-released from the bag, which, according to the researchers, may be a technical complication for the effective transport of the drug.
Cancer is starved by nitrogen. How to destroy cancer cells?
Peptides can also pass to cells without the help of reactive energy. Jungwirt's team, using fluorescence and electron microscopy and computer molecular simulations, discovered a mechanism based on membrane fusion induced by the peptides themselves. However, according to Jungwirth, the practical use of discoveries can only be speculated.
Jungwirth has long been working with his team on molecular processes in the cell membrane, opening up new ways to control these processes and potentially even more efficient ways to transport drug molecules to the site of action.
Jungwirth has published over 280 works in international journals, including Science, Nature Chemistry and PNAS. He is also the editor of the journal The Journal of Physical Chemistry, published by the American Chemical Society. Also popularizes learning in Respekt, Czech Radio and Czech Television.