People who regularly use cannabis they may need to double the sedative level In terms of non-users, when they go through medical procedures, it provides a small study.
Fentanyl, midazolam and propofol, the three sedatives that are commonly used endoscopic procedures, were compared to this investigation.
With "the continued increase in legalization and the use of cannabis, the field of anesthesia and sedatives needs deep studies," the authors of a study published on Monday Journal of the American osteopathic association.
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Wider use after legalization
On marijuana has gained popularity across the globe in recent years, in part, change of laws.
Between 2007 and 2015, the use of marijuana increased by 43% in the United States, where about 13.5% of adults consume cannabis, according to a report by the United Nations.
The use of cannabis in the world is estimated to include 183 million people, or about 4% of the adult population, in 2015.
How Can Increased Use Of Cannabis Affect Medical Care? Researchers at the community hospital in Grand Springs, in Colorado, they explored a small area of medical treatment: sedation.
They examined it a medical history of 250 patients who received endoscopic procedures between 1 January 2016 and 31 December 2017, years after the state legalized the recreational use of marijuana, especially in 2012.
Comparing cannabis users with those who do not use it, the researchers found that patients who reported smoking or ingesting it in food daily or weekly they asked for 14% more fentanyl, 20% more midazolam and 220% more propofol to achieve optimal sedation for routine procedures, including colonoscopes.
For example, an average of 13.83 milligrams of propofol needed, for 225 non-consumers to enter the unconscious state, while An average of 44.81 milligrams for 25 cannabis users.
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The authors of the study noted that some sedatives have side effects and the greater the dose, the greater the likelihood of problems.
Ask questions about cannabis in procedures "It can be an important tool for patient care planning and needs assessment and possible risks during endoscopic procedures", they wrote.
Very few participants
Dr. Roderick Eckhoff, a professor of anesthesia at the University of Pennsylvania, He said the study was interesting, but there was no rigor. "I will consider this as a pilot study that someone might take and make a more complete test," said a specialist who was not involved in the work.
One factor that worried him was that the study was retrospective: the researchers simply examined the medical records and compared any dose of sedation that was used for each patient, rather than controlling the exact amounts and comparing their effects.
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What is considered "sufficient" depends heavily on individual providers and surgeons, says Ekenhof. This "uncertainty" in combination with a small group – only 25% of the patients who consume it cannabis makes the results "very thin, at best".
Similar results may have not been seen in previous studies, he said. "Even if they give any propofol for a longer period of time, they will become somewhat tolerant of it, but not 200% ". Although more than 200 percent "resistance" may be "possible," Ekenhof said he would be surprised if he was ratified in a larger study.
Finally, he noted that patients are not always confident and do not tell doctors about everything they consume, and that can affect the results. "Some people who use marijuana also take other drugs recreational", he says.