Sunday , August 1 2021

Spinach can be the key to fighting depression or chronic pain


Two peptides that are natural metabolic products of Rubisco, proteins found in many plants such as spinach, can help develop new drugs that produce less side effects in the fight against alcohol disorders, chronic pain and the state of mind, according to research published in the journal "European Neuropsychopharmacolgy"

This finding provides a new avenue for the development of drugs that provide therapeutic relief to the patient without causing adverse side effects. "We are part of a new and exciting drug detection area, which aims to develop molecules that only activate cellular signaling pathways associated with their therapeutic effect." We found that these peptides selectively activate known useful paths without activating the pathways of the effects. secondary "on the receiver," explains his author, Richard van Rein.

Van Rhine, in collaboration with Professors Darcy Thider and Marcus Lill, actively seeks synthetic and computer strategies to improve these peptides and make them more effective. The researcher believes that "there are reasons for optimism," because the rubybyslin peptides are already being examined in preclinical studies of their ability to regulate dietary intake and are even commercially available in anti-aging products for the skin.

These preclinical studies state that peptides are bioavailable orally and are able to penetrate the blood-brain barrier that is needed for a drug for the effective treatment of central nervous system disorders.

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