Thursday , September 24 2020

The nicotine delivery is different for different e-cigarettes


A new study by researchers at Penn State College of Medicine found that different electronic cigarettes or "electronic nicotine delivery systems (ENDS)" have different rates of nicotine delivery to users. The most popular e-cigarette brand JUUL for example, has been found to deliver more nicotine at a faster rate than other brands. The study, titled "Nicotine Absorption Profile in Regular Users of Electronic Floor-Based Delivery System", was published in the latest issue of the journal. Open pit network.

Electronic cigarettes. Image credit: Nigat Nasibil / Sturstock

Electronic cigarettes. Image credit: Nigat Nasibil / Sturstock

Essessica Kingst, the first author of the study and a researcher at the institute, explained that there have been studies that have found that electronic cigarettes with cassettes containing higher concentrations of nicotine also give users low nicotine compared to traditional cigarettes. In order to prove the correct nicotine delivery capacity of these e-cigarettes, the team thus reviewed the nicotine delivery capacity of JUUL and other brands. FULUL is said to contain the highest concentration of nicotine in its substrate, Jingst said.

For this study, the team of researchers recruited six FUL users recruited between November 2018 and May 2019 and were asked to shoot on their devices for ten minutes at 20-second intervals. That's how a total of 30 shots were recorded. Blood samples for nicotine level testing were calculated before evaporation, during and after evaporation. The team used liquid chromatography and mass spectrometry (LCMS) to detect the amount of nicotine in the blood of participants.

Kingston said: "The FUL users we studied had almost three times the concentration of nicotine in their blood than most of the e-cigarette users we studied. FUL's nicotine intake is very similar to cigarettes. "Julian pieces of nicotine also contain the highest nicotine at 59 mg / ml," the researchers said. The results revealed, "Among experienced users taking 30 beats in 10 minutes, sub-based ENDS delivered an average nicotine increase of 28.6 ng / ml on average of 8.7 minutes."

In addition to nicotine levels, the team also asked participants about their desire, withdrawal symptoms, and anxiety levels before and after evaporation. To find out the level of addiction, they also took the Penn State Electronic Cigarette Addiction Index Questionnaire. The results revealed that these JUUL users had higher nicotine dependence based on their self-rated questionnaire. Their use and dependency was compared to the 3000 long-term users of other brands of cigarettes. In addition, anxiety levels dropped after evaporating with Wool, the researchers wrote.

Study co-author Athonathan Foulds, a professor of public health science, explained that these results are different from previous studies that have tried to say that e-cigarettes are less dependent on ordinary cigarettes. He said: "In previous studies we found that e-cigarette users were less dependent on smokers. However, the high nicotine delivery of the product and the results of this study suggest that JUL is probably addictive like cigarettes. "

The authors wrote: "This study is the first to our knowledge that UUL delivers greater and faster amplification of nicotine in the blood than has been reported for most other ENDS devices." They added: "Compared to studies reporting increased nicotine after smoking 1 cigarette, the nicotine delivery of this product was similar. The nicotine delivery capabilities of this ENDS device can contribute to its dependence as well as its ability to compete with market share cigarettes. "

The study authors recommend that non-smokers stop smoking e-cigarettes because they can be quite addictive. However, regular cigarette smokers can switch to less addictive and less nicotine-delivering e-cigarettes. Another co-author of the study, Richon Richie, a professor of public health at the College of Medicine, said: "In previous work, we found that FUL delivers lower levels of some harmful chemicals than cigarettes, and even some e-cigarettes."

However, Holds warned that FUL and some of the e-cigarette brands could be harmful to health. He said: "This type of product is probably addictive and is appealing to teens. But the same qualities that make them addictive can enable adult smokers to switch to a much less harmful form of nicotine consumption. "

His words were similar to findings published in a newspaper last month Pediatrics she said that more and more teenagers are becoming addicted to evaporation due to the wide range of candy and fruit flavors on offer. Researchers at the University of Southern California blamed these spicy cartridges for the teenage vapor epidemic and called for stricter regulations against them.

Newspaper reference:

Yingst JM, Hrabovsky S, Hobkirk A, Trushin N, Richie JP, Foulds J. The nicotine absorption profile of regular users of a Pod-based electronic delivery system. JAMA Netw Open. 2019; 2 (11): e1915494. doi:

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