The cavity has an area of two-thirds the size of Manhattan – and NASA researchers described the finding as "disturbing".
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The researchers previously warned that the Thwaites might have caused an iceberg collapse that could increase sea level levels by 10 meters.
The researchers expect to find some gaps between the ice and the foundation of the bottom of the Tvights, where ocean water could enter and melt the glacier from below.
The great size and explosive growth rate of the newly discovered hole surprised them.
Researcher Eric Rigot of the University of California, Irvine, said: "For years we have been suspected that the Tuvai were not firmly attached to the foundation under it.
"Thanks to the new generation of satellites, we can finally see the details."
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MORE: the complaint of the RSPPA per dog was killed and was tied to a tree branch in the middle of the road
The cavity was discovered by an ice-breaker radar in NASA's IceBridge, an air campaign that began in 2010, which explores the links between the polar regions and the global climate.
The researchers also used data from the constellation of the radars of Italian and German spaceborne synthetic vents.
These very high resolution data can be processed by a technique called radar interferometry to reveal how the surface of the floor below is moved between the images.
"The size of the cavity beneath the glacier plays an important role in melting," lead author of the study, Pietro Milillo of NASA, said.
"As more heat and water are below the glacier, it melts faster."
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