The experimental flu preparation, molnupiravir, showed surprisingly good results
A new antiviral drug, designated MK-4482 / EIDD-2801, or molnupiravir, manages to completely stop coronavirus transmission within 24 hours, according to a study by the Georgia Institute of Biomedicine. It is a recently developed experimental flu drug, but it has been shown to be a “side effect” and effective of COVID-19.
“This is the first demonstration of an oral drug that rapidly blocks the transmission of SARS-CoV-2 and may change the rules of the game,” said the researchers in a publication in the journal Natural Microbiology.
Preventing mass transmission of the virus until reliable vaccines are developed is key to controlling COVID-19 and mitigating the catastrophic effects of the pandemic. However, because molnupiravir is taken orally, treatment can be started at an early stage and this facilitates its effectiveness in three ways: suppressing the development of the infection to severe stages; shortening the infectious phase and consequently reducing the emotional and economic consequences of prolonged isolation of the patient; rapid suppression of local epidemics.
“We have previously found that MK-4482 / EIDD-2801 has a wide range of activities against respiratory RNA viruses and that oral treatment of infected animals with the drug reduces the number of viruses spread by several orders of magnitude, drastically reducing their transmission. the properties made MK-4482 / EIDD / 2801 a strong candidate for pharmacological control of KOVID-19 “, the researchers wrote.
They used ferment molnupiravir because they believed these small predators were a suitable model for research because they “easily spread SARS-CoV-2, but many do not develop a serious disease that is very similar to the spread of SARS-CoV-2.” “CoV-2 in young people.”
According to Joseph Wolf of the Plumper Laboratory and one of the study’s authors, the process was as follows: The team infected the ferrets with a coronavirus and then treated them with molnupiravir. During treatment, infected ferrets were released into healthy animals and no cases were reported in which they transmitted the infection. At the same time, drug-treated ferrets rapidly developed a placebo and recovered.