One of the disadvantages of aging is that skeletal muscle loses the ability to heal after the injury. The new research from the University of Pittsburgh implies the so-called. "longevity protein" Koto, and as a culprit and therapeutic goal.
The newspaper, published this week in the Natural communications, showed that, in young animals, the expression Kllotus shouts after muscular injury, while in old animals, it remains flat. By raising Koto's levels in old animals or by mitigating the effects of Koto's deficiency, researchers could regenerate the muscle after injury.
"We found that we succeeded, at least in part, to save the regenerative defect of older skeletal muscles," said Dr. Fabrisia Ambrosio, director of rehabilitation for UPMC International, associate professor of physiotherapy and rehabilitation at Pit and primary school at the McGowan Institute for Regenerative Medicine . "We saw functional levels of muscle regeneration in old animals that coincided with those of their young colleagues, suggesting that this could potentially be a therapeutic option along the way."
Given that Cloto acts through dysfunction of the mitochondria, the researchers gave Clotel deficiency animals, mitochondrial drugs called SS-31, which are currently in Phase III clinical trials. Treated animals have grown more new muscle tissue at the site of the injury compared to untreated controls, and their strength after healing has reached the level of genetically normal mice.
Similarly, injection of Cloto in older animals several days after the injury resulted in greater muscle mass and better functional healing than their salt-treated colleagues. Normal, healthy mice did not benefit from SS-31 after injury.
Clinically, these findings can be translated to older adults who either have suffered muscle injury or have undergone muscular harmful surgery. Giving them Cotto at the appropriate time can increase their regeneration of muscles and lead to a more complete recovery.
Ambrosio warns that time, dose and administration will require future research.
"If you only bombard Cloth muscles, we do not expect to see any functional benefits," Ambrosio said. "We found that imitating the profile of the time we see in young animals seems to be critical. We think this gives some insight into the therapeutic window."