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Germ transplant helps women with tough-to-treat vaginal infections



Germ transplant helps women with tough-to-treat vaginal infections

Bacterial vaginosis is a common infection in women that is usually easily treated with antibiotics. But for those who develop recurrent infections, treatment options have been limited.

Now, Israeli researchers report they were able to put recurrent infections into remission in four out of five women who received a "vaginal microbiome transplant." The transplant consists of healthy bacteria collected from the vaginal fluid of donors without condition, the researchers explained.

"Bacterial vaginosis, while not life-threatening, is an extremely common female disorder that can cause severe discomfort to women's lives, including severe discomfort, reduced self-esteem, problems in intimate relationships, social segregation and a variety of developing infectious gynecological risks. and obstetric complications, "said the study's senior author, Dr. Eran Elinav.

"By introducing this new treatment, we hope to take a step closer to providing an affordable solution to millions of women around the world," added Elinav, of the Weizmann Institute of Science in Israel and Germany.

Bacterial vaginosis affects up to one-third of reproductive-age women, the researchers said. Sometimes the infection causes no symptoms or it can cause a vaginal discharge that smells bad.

After treatment with an antibiotic, the relapse rate is about 30% after three months and as high as 50% to 70% within a year, according to the study. Ongoing antibiotic treatment may help with recurrent infections but can leave women at risk of other infections, such as yeast infections.

The current study included five women aged 27 to 47 years who had recurrent bacterial vaginosis. Their infections hadn't responded completely to antibiotics.

The researchers recruited three women to donate vaginal fluid to help restore the vaginal microbiomes of the affected women. Elinav said the fluid was screened for multiple viral and bacterial pathogens, much like blood donations.

Four of the five women had a complete remission, according to Elinav. Three of the women needed more than one "transplant" to achieve remission. He said the fifth woman had a partial remission.

"With this friendly takeover, the symptoms and complications associated with the dominance of bacterial vaginosis microbiome rapidly subside," he said.

The women who had improvement of their symptoms showed enrichment of their vaginal microbiome with Lactobacillus microbes. These bacteria have been linked to a healthy vaginal microbiome in past research.

The study authors weren't sure why the fifth woman didn't have a complete remission. Elinav said it's possible that her "bad" bacteria were stronger than the transplanted good bacteria.

She hopes future studies will help optimize donor selection and chances for success for all women. His team plans to start another study in the coming months, Elinav noted.

Dr. Mitchell Kramer, chair of obstetrics and gynecology at Northwell Health's Huntington Hospital in Huntington, N.Y., was not involved in the current report. He said, "This study provides an interesting, novel, and potentially effective treatment for those women who suffer from recurrent, intractable bacterial vaginosis, which can adversely affect an individual's life and have an adverse impact on their health and well-being."

While no adverse events were seen in the study, Kramer added that "care must be taken to screen donors as well to prevent transmission of other diseases with the transplant."

Plus, he said the treatment needs to be studied in a much larger group of women.

Results of the study were published Oct. 7 in Nature Medicine.


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More information:
Ahinoam Lev-Sagie et al. Vaginal microbiome transplantation in women with intractable bacterial vaginosis, Nature Medicine (2019). DOI: 10.1038 / s41591-019-0600-6

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