The relationship between pediatric oral infections and carotid adulthood arthrosclerosis was reported in the Study of Cardiovascular Risks in the Study on Young Finns, a current future group.
"Observation is a novel because there are no previous studies of childhood oral infections and the risk of cardiovascular disease," said Associate Professor Pirkko Pusinen of the University of Helsinki.
More importantly, progressive oral infections and infections – endodontic lesions and periodontitis – are associated with several cardiovascular risk factors and the risk of adult disease. In adults, periodontitis has been particularly studied extensively, and is currently considered an independent risk factor for atherosclerotic vascular diseases. It is also known that treatment of periodontitis reduces cardiovascular risk factors.
The association between pediatric oral infections and atherosclerosis was found in a study conducted at the University of Helsinki, the Department of Oral and Maxillofacial Disorders, in co-operation with the national cardiovascular risk in a research study on young fetuses. The study was published in JAMA Network Open.
The study was initiated in 1980, when clinical oral trials were conducted for 755 children aged 6, 9 and 12 years. The monitoring was completed in 2007, when the thickness of the carotid intima media was measured by ultrasound examination of the participants, who were then 33, 36 and 39 years old.
The follow-up was 27 years old, and cardiovascular risk factors were measured at several time points. Cumulative exposure to the risk factor was calculated both in childhood and in the adult period. Signs of oral infections and inflammation collected in the study covered cavities, seals, bleeding by sounding, and the depth of pocket on the pocket.
MORE MIGRATION OF Oral Infectious Diseases, A Bigger Risk for Atherosclerosis
Of all children, 68%, 87% and 82% had bleeding, caries and seals, respectively. There were no differences between boys and girls. A small periodontal was observed in 54% of children, and in boys it is more common than in girls. Only 5% of the examined mouths were fully healthy, while 61% and 34% of the children had one to three signs and four signs of oral infection, respectively.
"The number of signs that are significantly associated with cumulative exposure to cardiovascular risk factors in adulthood, but especially in childhood," said Professor Marcus Jonaola of the University of Turku.
Both caries and periodontal diseases in childhood were significantly related to the thickness of carotid artery intimal media in adulthood. The increase in the carotid artery wall indicates a progression of atherosclerosis and an increased risk of myocardial or cerebral infarction.
The researchers emphasized the conclusion: "Oral infections were an independent risk factor for subclinical atherosclerosis and their association with cardiovascular risk factors persisted through the entire monitoring. The prevention and treatment of oral infections is important already in childhood."
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