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Even low use in children can have a negative impact on health – new research



GPs in the UK carry out over 300m patient consultations every year and
at least a quarter of these deals with children. Almost two-thirds of such appointments are for coughs, sore throats, or earaches – diseases that young children usually get.

Doctors and nurses group these types of illnesses as "acute respiratory tract infections". They are considered to be "self-limiting", meaning that antibiotics have little or no benefit and that the illness will go away in time. However, in at least 30% of these consultations, antibiotics are prescribed. Required an estimated 13m unnecessary antibiotic prescriptions. This is not only wasteful but may also have unintended consequences for the child's health.

Indeed, in our new study of over 250,000 children in the UK, we found that preschool children who had received two or more antibiotic courses for acute respiratory tract infections in the preceding year had a 30% greater chance of not responding to subsequent treatment ( including the need for hospital referral and admission) compared to children who had not received any antibiotics. Our study specifically excluded children with long-term health conditions that would make them more prone to infections.

The resistance issue

Well known that using antibiotics unnecessarily drives bacteria to change and can lead to developing antibiotic resistance. But people tend to think that resistance only occurs in people who use antibiotics too frequently, for too long, or in patients with other medical conditions that make them sicker. This is not true.

Taking any antibiotic (whether appropriate or not) makes developing antibiotic resistance more likely. As our research shows, even relatively low antibiotic use has potential health implications and brings home the unnecessary impact of antibiotic use in children. And when you consider that many preschool children often have multiple illness episodes, potentially leading to several antibiotic courses, it makes the findings even more pertinent.

All antibiotics have an effect on the body, even when taken at a low dose.
Shutterstock / Toey Toey

At this stage, it is impossible to say for sure what the underlying causes are for children who have received more antibiotics showing a greater chance of not responding to subsequent treatments.

It may be, for example, due to the emergence of resistant bacteria. It could also be down to the disruption of the fragile gut microbiome in young children. And it may also be related to the pragmatic expectations of further treatment and the fact that they are probably unaware of the limited role of antibiotics in most childhood infections. Indeed, it's normal for childrens' cows to last longer than you might think – in fact, half a go for ten days and one in ten go for 25 days.

Long-term changes

Of course, GPs want to provide the best care possible for their patients. But they grapple with the decision to prescribe an antibiotic – thereby lowering an individual patient's risk of harm – rather than prescribing it, and lowering community risk.



Read more:
      Scientists alone can't solve the antibiotic resistance crisis – we need economists too


This decision is not always straightforward. And when uncertain, clinicians often err on the side of caution and prescribe. But our study found that children who received more antibiotics were also more likely to revisit a health professional within a 14-day period – which would inadvertently increase the workload of doctors and nurses.

Given that our findings show that even relatively low antibiotic use has short-term health implications for children, it is clear that fewer GPs are prescribing antibiotics in such instances, the better. But only on GPs and nurses, parents also need to be realistic about how long their child's illness may last.


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