Tuesday , January 26 2021

Scientific milestone: they managed to "resonate" the brain of a pig that was dead for four hours

A group of scientists succeed restore your mobile activity and circulatory in the pig's brain I was dead for four hours. It is a finding that can contribute to the treatment of brain diseases.

Experts at Yale University in the United States used the brain of a dead pig, extracted from a meat packing plant, and noticed how by isolating and using a specific chemical solution, they discovered many basic cellular functions. Earlier it was believed that these activities ended seconds or minutes after the flow of blood and oxygen was completed.

"The unchanged brain of a large mammal retains capacity – it is not recommended for the return of circulation and certain molecular and cellular activities, several hours after the circulatory stop, "said Nenad Sestan, a professor of neurology, comparative medicine, genetics and psychiatry.

However, the investigation also revealed that the brain was missing a recognizable global electrical signal associated with normal brain function. "At no time do we observe the type of organized electrical activity associated with perception or awareness," said Avonimir Vrselja, an expert in neuroscience. The agency EFE, Vrselja assured that clinically "this." it's not a living brain, but it's the brain cell-active"

Normally, cell death in the brain is considered an irreversible process. Because they are deprived of oxygen and blood supply, the signals of the brain's electrical activity and awareness of consciousness disappear within a few seconds, while energy reserves are reduced for several minutes.

However, Sestan's laboratory experts who focus on research on brain development and evolution have noticed that small tissue samples with which they routinely worked. reflect signals on mobile sustainability, even when the tissue was dead for several hours.

In the pig organ, subjected to analysis, which was four hours dead, this scientific team found preserved Integrity of nerve cells and restoration of certain functionality of vascular and neuronal cells.

Experts believe that this discovery can solve a complex problem: the inability to apply certain techniques to study the structure and function of the unchanged brain of a large mammal.

"Previously, we could only study the cells in the brain of large mammals under static or predominantly two-dimensional conditions, using small tissue samples outside their native environment," said scientist Stephano G. Daniele, who was part of this study. Daniele added that for the first time, explore the big brain in three dimensions, which increases the "ability to study complex cellular interactions and their association".

Although this progress will not have immediate clinical application, it is a new platform that can help physicians in the future to find ways to rescue brain functions in patients with stroke or to test the effectiveness of new therapies.

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